Developmental biology / Michael J. F. Barresi, Scott F. Gilbert
- Author:
- Barresi, Michael J. F., 1974-
- Published:
- New York, NY : Oxford University Press, [2020]
- Edition:
- Twelfth edition.
- Physical Description:
- xxi, 758 pages, various pagings ; 29 cm
- Additional Creators:
- Gilbert, Scott F., 1949-
- Contents:
- Machine generated contents note: 1.The Making of a Body and a Field: Introduction to Developmental Biology -- "How Are You, You?" Comparative Embryology and the Questions of Developmental Biology -- The Cycle of Life -- An animal's life cycle -- A flowering plant's life cycle -- Example 1: A Frog's Life -- Gametogenesis and fertilization -- Cleavage and gastrulation -- Organogenesis -- Metamorphosis and gametogenesis -- Example 2: Even a Weed Can Have a Flower-Full Life -- Reproductive and gametophytic phases -- Embryogenesis and seed maturation -- Vegetative phases: From sporophytic growth to inflorescence identity -- An Overview of Early Animal Development -- Patterns of cleavage -- Gastrulation: "The most important time in your life" -- The primary germ layers and early organs -- Understanding cell behavior in the embryo -- A Basic Approach to Watch Development -- Approaching the bench: Find it, lose it, move it -- Direct observation of living embryos -- Dye marking -- Genetic labeling -- Transgenic DNA chimeras -- Evolutionary Embryology -- Understanding the tree of life to see our developmental relatedness -- The developmental history of land plants -- Personal Significance: Medical Embryology and Teratology -- Genetic malformations and syndromes -- Disruptions and teratogens -- Coda -- 2.Specifying Identity: Mechanisms of Developmental Patterning -- Levels of Commitment -- Cell differentiation -- Cell fate maturation -- Autonomous Specification -- Cytoplasmic determinants and autonomous specification in the tunicate -- Conditional Specification -- Cell position matters: Conditional specification in the sea urchin embryo -- Syncytial Specification -- Opposing axial gradients define position -- 3.Differential Gene Expression: Mechanisms of Cell Differentiation -- Defining Differential Gene Expression -- A Quick Primer on the Central Dogma -- Evidence for Genomic Equivalence -- Anatomy of the Gene -- Chromatin composition -- Exons and introns -- Major parts of a eukaryotic gene -- The transcription product and how it is processed -- Noncoding regulatory elements: The on, off, and dimmer switches of a gene -- Mechanisms of Differential Gene Expression: Transcription -- Epigenetic modification: Modulating access to genes -- Transcription factors regulate gene transcription -- The gene regulatory network: Defining an individual cell -- Mechanisms of Differential Gene Expression: Pre-messenger RNA Processing -- Creating families of proteins through alternative pre-mRNA splicing -- Mechanisms of Differential Gene Expression: mRNA Translation -- Differential mRNA longevity -- Stored oocyte mRNAs: Selective inhibition of mRNA translation -- Ribosomal selectivity: Selective activation of mRNA translation -- microRNAs: Specific regulation of mRNA translation and transcription -- Control of RNA expression by cytoplasmic localization -- Mechanisms of Differential Gene Expression: Posttranslational Protein Modification -- Coda -- 4.Cell-to-Cell Communication: Mechanisms of Morphogenesis -- A Primer on Cell-to-Cell Communication -- Adhesion and Sorting: Juxtacrine Signaling and the Physics of Morphogenesis -- Differential cell affinity -- The thermodynamic model of cell interactions -- Cadherins and cell adhesion -- The Extracellular Matrix as a Source of Developmental Signals -- Integrins: Receptors for extracellular matrix molecules -- The Epithelial-Mesenchymal Transition -- Cell Signaling -- Induction and competence -- Paracrine Factors: Inducer Molecules -- Morphogen gradients -- Signal transduction cascades: The response to inducers -- Fibroblast growth factors and the RTK pathway -- FGFs and the JAK-STAT pathway -- The Hedgehog family -- The Wnt family -- The TGF-7beta; superfamily -- Other paracrine factors -- The Cell Biology of Paracrine Signaling -- Focal membrane protrusions as signaling sources -- Juxtacrine Signaling for Cell Identity -- The Notch pathway: Juxtaposed ligands and receptors for pattern formation -- Paracrine and juxtacrine signaling in coordination: Vulval induction in C. elegans -- 5.Stem Cells: Their Potential and Their Niches -- The Stem Cell Concept -- Division and self-renewal -- Potency defines a stem cell -- Stem Cell Regulation -- Pluripotent Cells in the Embryo -- Meristem cells of the Arabidopsis thaliana embryo and beyond -- Cells of the inner cell mass in the mouse embryo -- Adult Stem Cell Niches in Animals -- Stem cells fueling germ cell development in the Drosophila ovary -- Adult Neural Stem Cell Niche of the V-SVZ -- The neural stem cell niche of the V-SVZ -- The Adult Intestinal Stem Cell Niche -- Clonal renewal in the crypt -- Stem Cells Fueling the Diverse Cell Lineages in Adult Blood -- The hematopoietic stem cell niche -- The Mesenchymal Stem Cell: Supporting a Variety of Adult Tissues -- Regulation of MSC development -- The Human Model System to Study Development and Disease -- Pluripotent stem cells in the lab -- Induced pluripotent stem cells -- Organoids: Studying human organogenesis in a culture dish -- 6.Sex Determination and Gametogenesis -- Sex Determination -- Chromosomal Sex Determination -- The Mammalian Pattern of Sex Determination -- Gonadal sex determination in mammals -- Secondary sex determination in mammals: Hormonal regulation of the sexual phenotype -- Chromosomal Sex Determination in Drosophila -- Sex determination by dosage of X -- The Sex-lethal gene -- Doublesex: The switch gene for sex determination -- Environmental Sex Determination -- Gametogenesis in Animals -- PGCs in mammals: From genital ridge to gonads -- Meiosis: The intertwining of life cycles -- Spermatogenesis in mammals -- Oogenesis in mammals -- Sex Determination and Gametogenesis in Angiosperm Plants -- Sex Determination -- Gametogenesis -- Pollen -- The ovule -- 7.Fertilization Beginning a New Organism -- Structure of the Gametes -- Sperm -- The egg -- Recognition of egg and sperm -- External Fertilization in Sea Urchins -- Sperm attraction: Action at a distance -- The acrosome reaction -- Recognition of the egg's extracellular coat -- Fusion of the egg and sperm cell membranes -- Prevention of polyspermy: One egg, one sperm -- Activation of egg metabolism in sea urchins -- Fusion of genetic material in sea urchins -- Internal Fertilization in Mammals -- Getting the gametes into the oviduct: Translocation and capacitation -- In the vicinity of the oocyte: Hyperactivation, directed sperm migration, and the acrosome reaction -- Recognition at the zona pellucida -- Gamete fusion and the prevention of polyspermy -- Activation of the mammalian egg -- Fusion of genetic material -- Fertilization in Angiosperm Plants -- Pollination and beyond: The progamic phase -- Pollen germination and tube elongation -- Pollen tube navigation -- Double fertilization -- Coda -- 8.Snails, Flowers, and Nematodes: Different Mechanisms for Similar Patterns of Specification -- A Reminder of the Evolutionary Context That Built the Strategies Governing Early Development -- The diploblastic animals: Cnidarians and ctenophores -- The triploblastic animals: Protostomes and deuterostomes -- What's to develop next -- Early Development in Snails -- Cleavage in Snail Embryos -- Maternal regulation of snail cleavage -- Axis determination in the snail embryo -- Gastrulation in Snails -- The Nematode C. elegans -- Cleavage and Axis Formation in C. elegans -- Rotational cleavage of the egg -- Anterior-posterior axis formation -- Dorsal-ventral and right-left axis formation -- Control of blastomere identity -- Gastrulation of 66 Cells in C. elegans -- 9.The Genetics of Axis Specification in Drosophila -- Early Drosophila Development -- Fertilization -- Cleavage -- The mid-blastula transition -- Gastrulation -- The Genetic Mechanisms Patterning the Drosophila Body -- Segmentation and the Anterior-Posterior Body Plan -- Maternal gradients: Polarity regulation by oocyte cytoplasm -- The anterior organizing center: The Bicoid and Hunchback gradients -- The terminal gene group -- Summarizing early anterior-posterior axis specification in Drosophila -- Segmentation Genes -- Segments and parasegments -- The gap genes -- The pair-rule genes -- The segment polarity genes -- The Homeotic Selector Genes -- Generating the Dorsal-Ventral Axis -- Dorsal-ventral patterning in the oocyte -- Generating the dorsal-ventral axis within the embryo -- Axes and Organ Primordia: The Cartesian Coordinate Model -- 10.Sea Urchins and Tunicates: Deuterostome Invertebrates -- Early Development in Sea Urchins -- Early cleavage -- Blastula formation -- Fate maps and the determination of sea urchin blastomeres -- Gene regulatory networks and skeletogenic mesenchyme specification -- Specification of the vegetal cells -- Sea Urchin Gastrulation -- Ingression of the skeletogenic mesenchyme -- Invagination of the archenteron -- Early Development in Tunicates -- Cleavage -- The tunicate fate map -- Autonomous and conditional specification of tunicate blastomeres -- 11.Amphibians and Fish -- Early Amphibian Development -- Fertilization, Cortical Rotation, and Cleavage -- Unequal radial holoblastic cleavage -- The mid-blastula transition: Preparing for gastrulation -- Amphibian Gastrulation -- Epiboly of the prospective ectoderm -- Vegetal rotation and the invagination of the bottle cells -- Involution at the blastopore lip -- Convergent extension of the dorsal mesoderm -- Progressive Determination of the Amphibian Axes -- Specification of the germ layers -- The dorsal-ventral and anterior-posterior axes -- The Work of Hans Spemann and Hilde Mangold: Primary Embryonic Induction -- Molecular Mechanisms of Amphibian Axis Formation -- How does the organizer form? -- Functions of the organizer -- Induction of neural ectoderm and dorsal mesoderm: BMP inhibitors -- Conservation of BMP signaling during dorsal-ventral patterning -- Regional Specificity of Neural Induction along the Anterior-Posterior Axis --
Contents note continued: Specifying the Left-Right Axis -- Early Zebrafish Development -- Zebrafish Cleavages: Yolking Up the Process -- Gastrulation and Formation of the Germ Layers -- Progression of epiboly -- Internalization of the hypoblast -- The embryonic shield and the neural keel -- Dorsal-Ventral Axis Formation -- The fish blastopore lip -- Teasing apart the powers of Nodal and BMP during axis determination -- Left-Right Axis Formation -- 12.Birds and Mammals -- Early Development in Birds -- Avian Cleavage -- Gastrulation of the avian embryo -- Axis specification and the avian "organizer" -- Left-right axis formation -- Early Development in Mammals -- Mammalian cleavage -- Trophoblast or ICM? The first decision of the rest of your life -- Mammalian gastrulation -- Mammalian axis formation -- Twins -- Coda -- 13.Neural Tube Formation and Patterning -- Transforming the Neural Plate into a Tube: The Birth of the Central Nervous System -- Primary neurulation -- Secondary neurulation -- Patterning the Central Nervous System -- The anterior-posterior axis -- The dorsal-ventral axis -- Opposing morphogens -- All Axes Come Together -- 14.Brain Growth -- Neuroanatomy of the Developing Central Nervous System -- The cells of the developing central nervous system -- Tissues of the developing central nervous system -- Developmental Mechanisms Regulating Brain Growth -- Neural stem cell behaviors during division -- Neurogenesis: Building from the bottom up (or from the inside out) -- Glia as scaffold for the layering of the cerebellum and neocortex -- Signaling mechanisms regulating development of the neocortex -- Development of the Human Brain -- Fetal neuronal growth rate after birth -- Hills raise the horizon for learning -- Genes for brain growth -- Changes in transcript quantity -- Teenage brains: Wired and unchained -- 15.Neural Crest Cells and Axonal Specificity -- The Neural Crest -- Regionalization of the Neural Crest -- Neural Crest: Multipotent Stem Cells? -- Specification of Neural Crest Cells -- Neural Crest Cell Migration: Epithelial to Mesenchymal and Beyond -- Delamination -- The driving force of contact inhibition -- Collective migration -- Migration Pathways of Trunk Neural Crest Cells -- The ventral pathway -- The dorsolateral pathway -- Cranial Neural Crest -- The "Chase and Run" Model -- An elaborate collaboration of pushes and pulls -- Neural Crest-Derived Head Skeleton -- Cardiac Neural Crest -- Establishing Axonal Pathways in the Nervous System -- The Growth Cone: Driver and Engine of Axon Pathfinding -- Rho, Rho, Rho your actin filaments down the signaling stream -- Axon Guidance -- The Intrinsic Navigational Programming of Motor Neurons -- Cell adhesion: A mechanism to grab the road -- Local and long-range guidance molecules: The street signs of the embryo -- Repulsion patterns: Ephrins and semaphorins -- How Did the Axon Cross the Road? -- ...Netrin -- Slit and Robo -- The Travels of Retinal Ganglion Axons -- Growth of the retinal ganglion axon to the optic nerve -- Growth of the retinal ganglion axon through the optic chiasm -- Target Selection: "Are We There Yet?" -- Chemotactic proteins -- Target selection by retinal axons: "Seeing is believing" -- Synapse Formation -- 16.Ectodermal Placodes and the Epidermis -- Cranial Placodes: The Senses of Our Heads -- Cranial placode induction -- Otic-epibranchial development: A shared experience -- Morphogenesis of the vertebrate eye -- Formation of the eye field: the beginnings of the retina -- The lens-retina induction cascade -- The Epidermis and Its Cutaneous Appendages -- Origin of the epidermis -- The ectodermal appendages -- Signaling pathways you can sink your teeth into -- Ectodermal appendage stem cells -- 17.Paraxial Mesoderm: The Somites and Their Derivatives -- Cell Types of the Somite -- Establishing the Paraxial Mesoderm and Cell Fates along the Anterior-Posterior Axis -- Specification of the paraxial mesoderm -- Spatiotemporal collinearity of Hox genes determines identity along the trunk -- Somitogenesis -- Axis elongation: A caudal progenitor zone and tissue-to-tissue forces -- How a somite forms: The clock-wavefront model -- Linking the clock-wavefront to Hox-mediated axial identity and the end of somitogenesis -- Sclerotome Development -- Vertebrae formation -- Tendon formation: The syndetome -- Dermomyotome Development -- Determination of the central dermomyotome -- Determination of the myotome -- 18.Intermediate and Lateral Plate Mesoderm: Heart, Blood, and Kidneys -- Intermediate Mesoderm: The Kidney -- Specification of the Intermediate Mesoderm: Pax2, Pax8, and Lim1 -- Reciprocal Interactions of Developing Kidney Tissues -- Mechanisms of reciprocal induction -- Lateral Plate Mesoderm: Heart and Circulatory System -- Heart Development -- A minimalist heart -- Formation of the heart fields -- Specification of the cardiogenic mesoderm -- Migration of the cardiac precursor cells -- Initial heart cell differentiation -- Looping of the heart -- Blood Vessel Formation -- Vasculogenesis: The initial formation of blood vessels -- Angiogenesis: Sprouting of blood vessels and remodeling of vascular beds -- Hematopoiesis: Stem Cells and Long-Lived Progenitor Cells -- Sites of hematopoiesis -- The bone marrow HSC niche -- Coda -- 19.Development of the Tetrapod Limb -- Limb Anatomy -- The Limb Bud -- Hox Gene Specification of Limb Skeleton Identity -- From proximal to distal: Hox genes in the limb -- Determining What Kind of Limb to Form and Where to Put It -- Specifying the limb fields -- Induction of the early limb bud -- Outgrowth: Generating the Proximal-Distal Axis of the Limb -- The apical ectodermal ridge -- Specifying the limb mesoderm: Determining the proximal-distal polarity -- Turing's model: A reaction-diffusion mechanism of proximal-distal limb development -- Specifying the Anterior-Posterior Axis -- Sonic hedgehog defines a zone of polarizing activity -- Specifying digit identity by Sonic hedgehog -- Sonic hedgehog and FGFs: Another positive feedback loop -- Hox genes are part of the regulatory network specifying digit identity -- Generating the Dorsal-Ventral Axis -- Cell Death and the Formation of Digits and Joints -- Sculpting the autopod -- Forming the joints -- Evolution by Altering Limb Signaling Centers -- 20.The Endoderm: Tubes and Organs for Digestion and Respiration -- The Pharynx -- The Digestive Tube and Its Derivatives -- Specification of the gut tissue -- Accessory organs: The liver, pancreas, and gallbladder -- The Respiratory Tube -- Epithelial-mesenchymal interactions and the biomechanics of branching in the lungs -- 21.Metamorphosis: The Hormonal Reactivation of Development -- Amphibian Metamorphosis -- Morphological changes associated with amphibian metamorphosis -- Hormonal control of amphibian metamorphosis -- Regionally specific developmental programs -- Metamorphosis in Insects -- Imaginal discs -- Hormonal control of insect metamorphosis -- The molecular biology of 20-hydroxyecdysone activity -- Determination of the wing imaginal discs -- 22.Regeneration: The Development of Rebuilding -- Defining The Problem of Regeneration -- Regeneration, a Recapitulation of Embryonic Development? -- An Evolutionary Perspective on Regeneration -- Regenerative Mechanics -- Plant Regeneration -- A totipotent way of regenerating -- A plant's meri-aculous healing abilities -- Whole Body Animal Regeneration -- Hydra: Stem cell-mediated regeneration, orphallaxis, and epimorphosis -- Stem cell-mediated regeneration in flatworms -- Tissue-Restricted Animal Regeneration -- Salamanders: Epimorphic limb regeneration -- Defining the cells of the regeneration blastema -- Luring the mechanisms of regeneration from zebrafish organs -- Regeneration in Mammals -- Compensatory regeneration in the mammalian liver -- The spiny mouse, at the tipping point between scar and regeneration -- 23.Development in Health and Disease: Birth Defects, Endocrine Disruptors, and Cancer -- The Role of Chance -- Genetic Errors of Human Development -- The developmental nature of human syndromes -- Genetic and phenotypic heterogeneity -- Teratogenesis: Environmental Assaults on Animal Development -- Alcohol as a teratogen -- Retinoic acid as a teratogen -- Endocrine Disruptors: The Embryonic Origins of Adult Disease -- Diethylstilbestrol (DES) -- Bisphenol A (BPA) -- Atrazine: Endocrine disruption through hormone synthesis -- Fracking: A potential new source of endocrine disruption -- Transgenerational Inheritance of Developmental Disorders -- Cancer as a Disease of Development -- Development-based therapies for cancer -- Coda -- 24.Development and the Environment: Biotic, Abiotic, and Symbiotic Regulation of Development -- Developmental Plasticity: The Environment as an Agent in Producing Normal Phenotypes -- Diet-induced polyphenisms -- Predator-induced polyphenisms -- Temperature as an environmental agent -- Reaction norms in plants -- Larval settlement -- Stress as an agent: The hard life of spadefoot toads -- Developmental Symbioses -- Developmental symbioses in plants -- Mechanisms of developmental symbiosis: Getting the partners together -- Developmental symbiosis in the mammalian intestine -- Coda -- 25.Development and Evolution: Developmental Mechanisms of Evolutionary Change -- The Developmental Genetic Model of Evolutionary Change -- Preconditions for Evolution: The Developmental Structure of the Genome -- Modularity: Divergence through dissociation -- Molecular parsimony: Gene duplication and divergence -- Mechanisms of Evolutionary Change -- Heterotopy -- Heterochrony -- Heterometry -- Heterotypy -- Developmental Constraints on Evolution -- Physical constraints -- Morphogenetic constraints -- Pleiotropic constraints and redundancy -- Ecological Evolutionary Developmental Biology -- Plasticity-First Evolution -- Genetic assimilation in the laboratory -- Genetic assimilation in natural environments --
Contents note continued: Selectable Epigenetic Variation -- Evolution and Developmental Symbiosis -- The evolution of multicellularity -- The evolution of placental mammals -- Coda. - Subject(s):
- Genre(s):
- ISBN:
- 1605358223 hardcover
9781605358222 hardcover
9781605358246
160535824X - Note:
- Revised edition of: Developmental biology / Scott F. Gilbert, Michael J.F. Barresi. Eleventh edition. 2016.
- Bibliography Note:
- Includes bibliographical references and index.
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