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Modeling and Control of Cortical Spreading Depression at the Cellular Level

Author:
Van Wert, Stephen
Published:
[University Park, Pennsylvania] : Pennsylvania State University, 2020.
Physical Description:
1 electronic document
Additional Creators:
Schiff, Steven J.
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Open Access.
Summary:
Cortical spreading depression (SD) is a phenomenon where the brain undergoes a depression in its usual electrical activity, and this depression of activity spreads slowly across the brain. Since its initial discovery in 1944, research into SD has linked the behavior with clinical conditions such as migraine, stroke, and epilepsy. At the cellular level, there are several changes that have been identified during SD. One notable effect is the large change in cellular ion concentrations that is sustained for a duration longer than would be seen with normal activity. While these and other properties of SD have been added into our understanding of the behavior, much remains to be studied in SD. This present study aims to contribute to the explanation at the cellular level with mechanisms that provide more detail for the characterization of ion concentrations that are an important marker of SD. Additionally, the model includes a mechanism by which an applied electric field might intervene in SD's propagation. The presented model thus not only provides some insight into possible cellular mechanisms of SD, but it also could be used in control applications that might treat the related disorders.
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Dissertation Note:
M.S. Pennsylvania State University 2020.
Technical Details:
The full text of the dissertation is available as an Adobe Acrobat .pdf file ; Adobe Acrobat Reader required to view the file.
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