Amide Bond Activation
- Author:
- Szostak, Michal
- Published:
- MDPI - Multidisciplinary Digital Publishing Institute 2019
- Physical Description:
- 1 electronic resource (466 p.)
Access Online
- mdpi.com , Open Access: DOAB: download the publication
- directory.doabooks.org , Open Access: DOAB: description of the publication
- Language Note:
- English
- Restrictions on Access:
- Open Access Unrestricted online access
- Summary:
- The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N-C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.
- Other Subject(s):
- N-heterocyclic carbene
- non planar amide
- ruthenium (Ru)
- physical organic chemistry
- gemcitabine prodrug
- pyramidal amides
- bridged sultams
- catalysis
- dipeptides
- N-(1-naphthyl)acetamide
- C-N ? bond cleavage
- steric effects
- peptide bond cleavage
- transition-metal-free
- palladium
- N-heterocyclic carbenes (NHCs)
- addition reaction
- C-O activation
- rhodium
- metal complexes
- carbanions
- thioamidation
- amide bond
- intramolecular catalysis
- antiviral activity
- additivity principle
- pre-catalysts
- C-N bond cleavage
- bridged lactams
- C-H acidity
- arynes
- twisted amides
- organic synthesis
- amination
- Suzuki-Miyaura
- tert-butyl
- cyclopentadienyl complexes
- C-S formation
- enzymes
- DFT study
- sulfonamide bond
- N
- HERON reaction
- primaquine
- entropy
- amide activation
- amidation
- synthesis
- amide hydrolysis
- carbonylicity
- amide bond activation
- amide bond resonance
- aminosulfonylation
- molecular dynamics
- model compound
- in situ
- amide
- homogeneous catalysis
- heterocycles
- anomeric effect
- multi-component coupling reaction
- kinetic
- excited state
- C-H bond cleavage
- palladium catalysis
- amides
- thiourea
- formylation
- alkynes
- cis/trans isomerization
- amide C-N bond activation
- intein
- C-H functionalization
- succindiamide
- amide bonds
- crown ether
- aminoacylation
- directing groups
- cytostatic activity
- reaction thermodynamics
- acyl transfer
- transition metals
- N-dimethylformamide
- DMAc
- acylative cross-coupling
- C-H/C-N activation
- nickel catalysis
- antibacterial screening
- sodium
- aryl thioamides
- Winkler-Dunitz parameters
- catalyst
- N-dimethylacetamide
- base-catalyed hydrolysis
- nitrogen heterocycles
- cross-coupling
- insertion
- amidicity
- nitro-aci tautomerism
- activation
- carbonylation
- transamidation
- amine
- distortion
- Pd-catalysis
- rotational barrier energy
- hypersensitivity
- N-C activation
- metabolic stability
- [2+2+2] annulation
- twisted amide
- protease
- cyanation
- amide resonance
- trialkylborane
- catalysts
- biofilm eradication
- pharmacokinetics
- pancreatic cancer cells
- DMF
- aryl esters
- Michael acceptor
- fumardiamide
- water solvation
- ester bond activation
- cyclization
- nuclear magnetic resonance
- secondary amides
- reaction mechanism
- density functional theory
- density-functional theory
- amino acid transporters
- ISBN:
- books978-3-03921-204-0
9783039212033
9783039212040 - Collection:
- DOAB Library.
- Terms of Use and Reproduction:
- Creative Commons https://creativecommons.org/licenses/by-nc-nd/4.0/
View MARC record | catkey: 33189333