The Evolution and Development of the Antibody Repertoire

Published: Frontiers Media SA 2015
Physical Description: 1 online resource (122 p.)

Access Online

journal.frontiersin.org , Open Access: DOAB, download the publication
directory.doabooks.org , Open Access: DOAB: description of the publication

Availability

Finding items...

Series

Frontiers Research Topics

Language Note

English

Restrictions on Access

Open Access Unrestricted online access

Summary

Although at first glance mechanisms used to create the variable domains of immunoglobulin appear to be designed to generate diversity at random, closer inspection reveals striking evolutionary constraints on the sequence and structure of these antigen receptors, suggesting that natural selection is operating to create a repertoire that anticipates or is biased towards recognition of specific antigenic properties. This Research Topics issue will be devoted to an examination of the evolution of antigen receptor sequence at the germline level, an evaluation of the repertoire in B cells from fish, pigs and human, an introduction into bioinformatics approaches to the evaluation and analysis of the repertoire as ascertained by high throughput sequencing, and a discussion of how study of the normal repertoire informs the construction or selection of in vitro antibodies for applied purposes.

Subject(s)

Medicine

Other Subject(s)

ISBN

978-2-88919-549-7
9782889195497

Collection

DOAB Library.

Terms of Use and Reproduction

Creative Commons https://creativecommons.org/licenses/by/4.0/

View MARC record | catkey: 33193540