Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions

Author:: Lluis Fajas
Published:: Frontiers Media SA 2018
Physical Description:: 1 electronic resource (70 p.)
Additional Creators:: Albert Giralt

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www.frontiersin.org , Open Access: DOAB: download the publication
directory.doabooks.org , Open Access: DOAB: description of the publication

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Language Note:

English

Restrictions on Access:

Open Access Unrestricted online access

Summary:

Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent a major metabolic challenge. Noteworthy, metabolic reprogramming is now considered one of the hallmarks of cancer. However, the one size fits all rarely applies to the metabolic rewiring occurring in cancer cells, which ultimately depends on the combination of several factors such as the tumor's origin, the specific genetic alterations and the surrounding microenvironment. In the present Research Topic, we compile a series of articles that discuss different metabolic adaptations that proliferating cells undergo to sustain growth and division, as well as the potential therapeutic window to treat certain pathologies, with a special focus on cancer.

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ISBN:

978-2-88945-484-6
9782889454846

Collection:

DOAB Library.

Terms of Use and Reproduction:

Creative Commons https://creativecommons.org/licenses/by/4.0/

View MARC record | catkey: 33195952