Chapter Cell Culture and Maintenance of the Evolutionary Forms of Trypanosoma cruzi for Studies of Parasitic Biology

Author: Gonçalves, Moreno
Published: [Place of publication not identified] : InTechOpen, 2019.
Physical Description: 1 online resource
Additional Creators: Castelo, Branco, José, da Silva Júnior, Laura, Araújo, Maria, Queiroz, Sousa, Silva, Tavares, Donato, Thays, da Silva Rodrigues, and Wysllas, de Freitas Oliveira

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Language Note

English

Restrictions on Access

Open Access Unrestricted online access

Summary

This chapter aims to present and discuss the main cell culture techniques used for the growth and maintenance of the different evolutionary forms of the protozoan Trypanosoma cruzi, the etiologic agent of the Chagas disease. Chagas disease is a neglected tropical disease endemic in several Latin American countries. Here, we intend to present the main difficulties, advantages, and disadvantages of using Trypanosoma cruzi cell culture in parasitic biology. Finally, we present the main research opportunities in the context of Trypanosoma cruzi parasitic biology using cell culture techniques, such as drug development, characterization of pharmacological targets, molecular markers for diagnosis, structural biology, and many other biomedical applications.

Subject(s)

Medical parasitology

Other Subject(s)

Trypanosoma cruzi, Chagas disease, cell culture, in vitro assay, metacyclogenesis

ISBN

intechopen.84733

Collection

OAPEN Library.

Terms of Use and Reproduction

Creative Commons https://creativecommons.org/licenses/by/3.0/

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