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Herpesviruses and Immunity [electronic resource] / edited by Peter G. Medveczky, Herman Friedman, Mauro Bendinelli

Published
New York, NY : Springer US : Imprint: Springer, 2002.
Edition
1st ed. 2002.
Physical Description
XXI, 317 pages : online resource
Additional Creators
Medveczky, Peter G., Friedman, Herman, 1931-2007, Bendinelli, Mauro, and SpringerLink (Online service)
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Contents
Evasion and Obstruction -- Immunopathology of Herpesvirus Infections -- HSV Gene Expression during Latent Infection and Reactivation -- T Cell Activation and Lymphokine Induction in Herpesvirus saimiri Immortalized Cells -- Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV8) and the Etiology of KS -- Immunobiology of Murine Gamma Herpesvirus-68 -- EBV and B Cell Lymphomas -- Immune Responses to Epstein-Barr Viral Infection -- EBV Persistence in Vivo -- Epstein-Barr Virus Vaccines -- Inhibition of MHC Class I Function by Cytomegalovirus -- Cell-Mediated Immunity against Varicella-Zoster Virus -- Complement Control Proteins of Rhadinoviruses.
Summary
Although virology and immunology are now considered separate disciplines, history shows that these areas ofinvestigation always overlapped and one cannot really exist without the other. This trend has become particularly significant and fruitful in the past few years in the area of herpesvirus research. The genomes of the most important herpesviruses have been sequenced, a significant portion of their genes have been identified, and many secrets of regulation of gene expr- sion have been unraveled. Now this progress sets the stage for a true revolution in herpesvirus research: analysis of interactions between the host and the virus. Because herpesviruses can induce, suppress, and fool the immune system, the most productive herpes virologists are also expert immunologists, and the current results of this interdisciplinary effort are truly remarkable. Because herpesviruses cause many important human diseases, the development of vaccines against these agents is a very significant goal. This effort is also very challenging because of the complexity of herpes viruses and the lack of sufficient information about immune responses. The remarkable ability of herpesviruses to escape immune responses is - other feature that brings immunology and virology together. Herpesviruses - code many proteins that interact with and down-regulate some key elements of the immune system. This property of herpesviruses represents a major challenge in developing strategies against these viruses. On the positive side, these viral proteins also provide novel tools for analyzing specific immune reactions and molecular mechanisms.
Subject(s)
ISBN
9780306468087
Digital File Characteristics
PDF
text file
Part Of
Springer Nature eBook
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