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30 years old, O-GlcNAc reaches age of reason [electronic resource] : regulation of cell signaling and metabolism by O-GlcNAcylation / topic editors, Tony Lefebvre, CNRS/UMR 8576, University Lille 1, Villeneuve d'Ascq, France, Tarik Issad, INSERM U1016, CNRS UMR8104, University Paris Descartes, Paris, France

Published
[Lausanne, Switzerland] : Frontiers Media SA, [2015]
Physical Description
1 online resource (113 pages)
Additional Creators
Issad, Tarik and Lefebvre, Tony, 1973-
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Summary
"Hundreds post-translational modifications (PTM) were characterized among which a large variety of glycosylations including O-GlcNAcylation. Since its discovery, O-GlcNAcylation has emerged as an unavoidable PTM widespread in the living beings including animal and plant cells, protists, bacteria and viruses. In opposition to N- and O-glycosylations, O-GlcNAcylation only consists in the transfer of a single N-acetylglucosamine moiety through a beta-linkage onto serine and threonine residues of proteins confined within the cytosol, the nucleus and the mitochondria. The O-GlcNAc group is provided by UDPGlcNAc, the end-product of the hexosamine biosynthetic pathway located at the crossroad of cell metabolisms, making O-GlcNAcylation a PTM which level tightly reflects nutritional status; therefore regulation of cell homeostasis should be intimately correlated to lifestyle and environment. Like phosphorylation, with which it can compete, O-GlcNAcylation is reversible. This versatility is managed by OGT (O-GlcNAc transferase) that transfers the GlcNAc group and OGA (O-GlcNAcase) that removes it. Also, like its unsweetened counterpart, O-GlcNAcylation controls fundamental processes, e.g. protein fate, chromatin topology, DNA demethylation and, as recently revealed, circadian clock. Deregulation of O-GlcNAc dynamism may be involved in the emergence of cancers, neuronal and metabolic disorders such as Alzheimer's or diabetes respectively"--Page 3.
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ISBN
9782889195916 (pdf)
Note
"Published in: Frontiers in endocrinology."
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Includes bibliographical references.
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Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode
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