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THE ROLE OF TISSUE HYPOXIA IN CHEMICAL PROTECTION

Author
van der Meer, C.
Published
[Place of publication not identified] : [publisher not identified], 1959.
[Oak Ridge, Tennessee] : [U.S. Atomic Energy Commission], 1959.
Physical Description
microopaque : positive ; 8 x 13 cm
Additional Creators
Cohen, J. A. and van Bekkum, D. W.

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Summary
Chemical substances which protect mice against the lethal effects of total-body irradiation may be divided in to several groups according to different mechanisms of the protective action. Several compounds, all of which belong to the biological amines, were found to be completely devoid of protective activity towards isolated cells, while being excellent protectors for mice. Consequently, it his been postulated that these compounds protect the intact animal by way of their pharmacological effects, e.g., on the vascular system or on the central nervous system. Such effects may resuit in localized or general hypoxia. Protective dosages of histamine and epinephrine were found to induce hypoxia of the spleen. The protection obtained under these conditions has been compared with the protective effects of reduced oxygen tension during irradiation. From the results obtained the conclusion was reached that the protective action of these amines is largely, if not wholly, due to the production of hypoxia in the hematopoietic tissues. It remains therefore difficult to maintain the hypothesis that these protectors act by combining with radicals produced by the radiation in the living cells. This conclusion is further supported by the results obtained with combinations of a number of protective substances and their pharmacological antaponists. Investigations on a number of protective sulfhydryl compounds are also reported. Evidence is presented which indicates that a different mechanism of action may be involved. (auth)
Report Numbers
A/CONF.15/P/556
Other Subject(s)
Collection
U.S. Atomic Energy Commission depository collection.
Note
NSA number: NSA-13-006124
OSTI Identifier 4271116
Research organization: National Defence Research Council T.N.O., Rijswijk-ZH, The Netherlands.
View MARC record | catkey: 38045809