DISTRIBUTION OF 6-AZAURACIL-4,5-14C AND ITS RIBOSIDE IN NORMAL AND TUMOROUS ANIMAL TISSUES

Author: Habermann, V.
Published: [Place of publication not identified] : [publisher not identified], 1959.
[Oak Ridge, Tennessee] : [U.S. Atomic Energy Commission], 1959.
Physical Description: microopaque : positive ; 8 x 13 cm
Additional Creators: Sorm, F.

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Summary

The distribution of azauracil and its riboside in normal and tumor tissues and of the metabolic derivatives of azauracil in tumor cells was followed after injection of both preparations to mice with Ehrlich ascites tumor. Two hours after the interperitoneal injection of azauracil the relative activity of the tumor cells calculated per mg of dry substance was lower than the activity of the other tissues which had been investigated, in spite of the high concentration of azauracil in the surrounding ascitic exudate. The relative activity was 10 to 50 times higher than that of other tissues after the application of azauracil riboside. It is interesting to note that, unlike azauracil, the riboside barely penetrates into the central nervous system. When the metabolic changes resulting from the application of azauracil were investigated, the activity in the tumor cells was found in the free azauracil and about 30% in azauracil riboside- 5'phosphate. When azauracil riboside was applied, almost all the activity in the tumor cells was present in azauracil monophosphate. None of the above preparations had been incorporated into the nucleic acids of the tumor cells. These results show that azauracil and its riboside interfere with the nucleic acid metabolism at the pyrimidine nucleotide stage. (auth)

Report Numbers

A/CONF.15/P/2126

Other Subject(s)

Collection

U.S. Atomic Energy Commission depository collection.

Note

NSA number: NSA-13-006287
OSTI Identifier 4287795
Research organization: Czechoslovakia.

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