PATHOGENESIS AND REGENERATION OF RADIATION INDUCED BONE MARROW INJURY, AND THERAPEUTIC IMPLICATIONS

Author: Fliedner, T. M.
Published: United States : [publisher not identified], 1962.
[Oak Ridge, Tennessee] : [U.S. Atomic Energy Commission], 1962.
Physical Description: microopaque : positive ; 8 x 13 cm
Additional Creators: Bond, V. P. and Cronkite, E. P.

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Summary

The hematological data of patients of 4 radiation accidents, Rongelap 1954, Oak Ridge 1958, Vinca 1958, and Lockport 1960, are reviewed and compared. The blood cell curves appear to show three phases. An initial phase at about 8 to 10 days, a phase of transient or abortive regenerations, and a phase of final effective recovery were demonstrated. These phases in the blood are preceded and caused by particular events in the bone marrow. Evidence was brought forward that transient rises in leukocytes and reticulocytes associated with a delayed platelet disappearance curve are associated with a marrow capable of spontaneous recovery. In patients with inhomogenous total--body irradiation, the transient rise may iead directly to effective recovery. Immediate decline of all blood cell elements without evidence of further, even abortive attempts of marrow regeneration must be considered as evidence for a iethal bone marrow dose and extremeiy serious complications may be expected. The clinical implications of these analyses are outlined and the diagnostic possibilities described. (auth)

Report Numbers

BNL-6018

Other Subject(s)

Collection

U.S. Atomic Energy Commission depository collection.

Note

DOE contract number: AT-30-2-GEN-16
NSA number: NSA-17-007906
OSTI Identifier 4736070
Research organization: Brookhaven National Lab., Upton, N.Y.

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