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Development of Transparent Ultrasonic Transducers for Biomedical Applications

Author:
Osman, Mohamed
Published:
[University Park, Pennsylvania] : Pennsylvania State University, 2022.
Physical Description:
1 electronic document
Additional Creators:
Hayes, Daniel
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Restricted (PSU Only).
Summary:
Dual-modality ultrasound and photoacoustic (USPA) imaging using conventional ultrasound arrays has enabled real-time imaging of physiological information related to cancer, neurological and vascular diseases. However, off-axis illumination around the ultrasound arrays leads to bulky imaging head and shadow illumination below the transducer. These issues not only demand significant acoustic coupling but also limit imaging speed. Transparent ultrasound transducer (TUT) technology has been recently introduced for easy co-alignment of optical illumination and acoustic detection paths on the tissue surface, which allows development of compact hand-held USPA devices for use with minimum acoustic coupling. However, TUTs suffer from narrow bandwidth and low pulse-echo sensitivity due to the lack of suitable transparent acoustic matching and backing layers. To maximize the TUT's potential for USPA imaging, we studied transparent cover glass, parylene C and translucent glass beads in transparent epoxy (GB) as an acoustic matching layer for the TUTs. Lithium niobate based TUTs (LN-TUTs) with various transparent and transulcent matching layers were studied both theoretically and experimentally for acoustic and optical properties. Those studies demonstrated that the two matching layers design of cover glass slide, and parylene C and GB matching layer have significantly enhanced the pulse echo sensitivity and bandwidth of the TUTs. Moreover, the GB matching layer served as a light diffuser to help achieve uniform optical fluence on the tissue surface and also improved the PA signal bandwidth. The proposed TUTs are low in cost, easy to manufacture using conventional ultrasound transducer fabrication tools, acoustically compatible with soft tissue, and significantly minimized the use of the acoustic coupling medium during real-time USPA imaging. In the future, the TUTs based USPA imaging are intended to meet the needs of preclinical and clinical applications.
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Dissertation Note:
M.S. Pennsylvania State University 2022.
Technical Details:
The full text of the dissertation is available as an Adobe Acrobat .pdf file ; Adobe Acrobat Reader required to view the file.
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