CALCIUM TURNOVER STUDIES IN MAN

Author:: Corey, K. R.
Published:: United States : [publisher not identified], 1963.
[Oak Ridge, Tennessee] : [U.S. Atomic Energy Commission], 1963.
Physical Description:: microfiche : negative ; 8 x 13 cm
Additional Creators:: Greebberg, D., Kenny, P., Laughlin, J. S., Merlino, M., and Weber, D.

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Summary:

Methods for determination of calcium turnover in man with radioisotopes are presented and the clinical use of various techniques is evaluated. In the discussion of kinetic analyses, some important observations were made. The accretion rate calculation can be made independent of the number of compartments in the exchangeable calcium pool, and thus is not distorted by approximate estimations of this pool. However, if the exchangeable calcium pool is calculated with the isotope dilution technique, and the accretion rate obtained from this value by the total turnover equation, then an error is introduced into the value of the accretion rate. It was also pointed out that the multicompartment treatment is more appropriate than the customary single compartment analysis and utilizes all available information. Since the pool size has been of little clinical use so far, it was suggested that multicompantment analyses be used in the future. At present, no accepted model exists which can account for all data obtained in tracer studies and in particular for the last part of the serum disappearance curve. Preliminary results of long term studies of the retention in bones of strontium-85 was presented. These show that there is measurable turnover of tracer deposited in bone even several months after injection. (auth)

Report Numbers:

CONF-355-4

Other Subject(s):

Collection:

U.S. Atomic Energy Commission depository collection.

Note:

DOE contract number: AT(30-1)-910
NSA number: NSA-18-013416
OSTI Identifier 4094191
Research organization: Sloan-Kettering Inst. for Cancer Research, New York.

Funding Information:

Sponsored by US Atomic Energy Commission (AEC).

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