Emerging fluorinated motifs : synthesis, properties and applications / edited by Dominique Cahard, Jun-An Ma.
- Published
- Weinheim : Wiley-VCH, 2020.
- Physical Description
- 1 online resource (868 pages)
- Additional Creators
- Cahard, Dominique and Ma, Jun-An.
Access Online
- Contents
- 1.2.3 Transition-Metal-Catalyzed Radical Difluoromethylation of (Hetero)aryl Metals/Halides and Beyond -- 1.2.4 Radical C-H Bond Difluoromethylation of (Hetero)aromatics -- 1.3 Difluoroalkylation of Aromatics -- 1.3.1 Transition-Metal-Catalyzed Phosphonyldifluoromethylation of (Hetero)aromatics -- 1.3.2 Transition-Metal-Catalyzed Difluoroacetylation of (Hetero)aromatics and Beyond -- 1.3.3 Other Catalytic Difluoroalkylations of (Hetero)aromatics -- 1.4 Outlook -- References -- Chapter 2 Difluoromethylation and Difluoroalkylation of Aliphatic Unsaturated C=C, C≡C, and N=C Bonds -- 2.1 Introduction, Cover -- Title Page -- Volume 1 -- Copyright Page -- Volume 1 -- Title Page -- Volume 2 -- Copyright Page -- Volume 2 -- Contents -- Volume 1 -- Contents -- Volume 2 -- Preface -- Volume 1 -- Part I Carbon-Linked Fluorine-Containing Motifs -- Chapter 1 Difluoromethylation and Difluoroalkylation of (Hetero)Arenes: Access to Ar(Het)-CF2H and Ar(Het)-CF2R -- 1.1 Introduction -- 1.2 Difluoromethylation of (Hetero)aromatics -- 1.2.1 Transition-Metal-Mediated/Catalyzed Nucleophilic Difluoromethylation of (Hetero)aromatics -- 1.2.2 Catalytic Metal-Difluorocarbene-Involved Coupling (MeDIC) Reaction, 2.2 Difluoromethylation of C═C Double Bonds -- 2.2.1 Intermolecular Difunctionalization of C=C Double Bonds -- 2.2.1.1 By Means of BrCF2P(O)(OR)2 -- 2.2.1.2 By Means of Ph3P+CF2CO2− -- 2.2.1.3 By Means of HCF2R (R=CO2H, SO2NHNHBoc) -- 2.2.1.4 By Means of Selectfluor -- 2.2.1.5 By Means of BrCF2CO2Et -- 2.2.2 Difluoromethylation of C═C Double Bonds and Subsequent Cyclization -- 2.2.3 Difluoromethylation of C═C Double Bonds with Rearrangements -- 2.3 Difluoromethylation of Isocyanides -- 2.4 Difluoromethylation of Alkynes -- 2.5 Conclusion and Perspectives -- References, 3.1.7 Miscellaneous Reagents -- 3.2 Electrophilic Difluoromethylation and Difluoroalkylation -- 3.2.1 By Means of Difluorocarbene Reagents -- 3.2.2 By Means of CF3X (X═H, I, TMS) Reagents -- 3.2.3 By Means of I(III)-CF2SO2Ph Reagent -- 3.2.4 By Means of S-((Phenylsulfonyl)difluoromethyl)thiophenium Salts -- 3.3 Free Radical Difluoromethylation and Difluoroalkylation -- 3.3.1 By Means of Iododifluoroacetates -- 3.3.2 By Means of CF2Br2, CF2BrCl, or TMSCF2Br -- 3.3.3 By Means of Phosphorus-containing Reagents -- 3.3.4 By Means of BrCF2CO2Et -- 3.3.5 By Means of Halodifluoroketone or -Amide, and Chapter 3 Difluoromethylation and Difluoroalkylation in C(sp3) Centers and C═O, C═C, and C═N Bonds -- 3.1 Nucleophilic Difluoromethylation and Difluoroalkylation -- 3.1.1 By Means of XCF2PO(OEt)2 -- 3.1.2 By Means of BrCF2CO2Et and BrCF2CH═CH2 -- 3.1.3 By Means of Difluoromethylcadmium, Difluoromethylcopper, and Difluoromethylzinc Reagents -- 3.1.4 By Means of Difluoroalkylated Sulfone Reagents (XCF2SO2Ar) and Difluoromethylated Sulfoxides -- 3.1.5 By Means of Difluoroalkylated Silanes and Trifluoromethylsilane Reagents -- 3.1.6 By Means of Difluoromethyl Sulfoximine Reagent
- Subject(s)
- ISBN
- 9783527824342 (electronic bk. ; oBook)
3527824340 (electronic bk. ; oBook)
9783527824328
3527824324
9783527346813
9783527824335 (ePub ebook)
3527824332 - Note
- 3.3.6 By Means of HCF2I and PhCH2CF2I
- Bibliography Note
- Includes bibliographical references and index.
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