Mass spectrometry-based metabolomics in clinical and herbal medicines : strategies, technologies and applications / edited by Aihua Zhang, Wanying Wang

Published: Weinheim, Germany : Wiley-VCH, 2022.
Physical Description: 1 online resource (286 pages)
Additional Creators: Zhang, Aihua (Of National TCM Key Laboratory of Serum Pharmacochemistry) and Wang, Wanying

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Contents

Cover -- Title Page -- Copyright -- Contents -- Preface -- Chapter 1 Current State of the Art of High-Throughput Metabolomics -- 1.1 Introduction -- 1.2 Metabolomics -- 1.3 Mass Spectrometry Technology -- 1.4 Recent Advancements and Applications -- 1.4.1 Disease Diagnoses and Metabolism -- 1.4.2 Metabolic Mechanisms -- 1.4.3 Drug Efficacy -- 1.4.4 Nutrition -- 1.4.5 Plant Biology -- 1.5 Limitation -- 1.6 Conclusions and Future Perspectives -- Acknowledgments -- References -- Chapter 2 Innovations in Analytical Techniques of Metabolomics -- 2.1 Introduction, 2.2 Current Analytical Technologies of Metabolomics -- 2.3 Chromatography Platform -- 2.3.1 Gas Chromatography Technique -- 2.3.2 Liquid Chromatography Technique -- 2.3.3 Supercritical Fluid Chromatography Technique -- 2.3.4 Capillary Electrophoresis Chromatography Technique -- 2.4 Mass Spectrometry Platform -- 2.4.1 GC-MS Technique -- 2.4.2 LC-MS Technique -- 2.4.3 SFC-MS Technique -- 2.4.4 CE-MS Technique -- 2.5 Nuclear Magnetic Resonance Platform -- 2.6 Comprehensive and Multidimensional Analytical Platform -- 2.7 Conclusions -- Acknowledgments -- References, Chapter 3 Sample Preparation Method for Mass Spectrometry-Based Metabolomics -- 3.1 Introduction -- 3.2 Sample Collection and Storage -- 3.2.1 Urine -- 3.2.2 Plasma and Serum -- 3.2.3 Cerebrospinal Fluids -- 3.2.4 Tissue Homogenates -- 3.2.5 Saliva -- 3.3 Sample Preparation and Processing -- 3.4 Application -- 3.5 Future Development -- Acknowledgments -- References -- Chapter 4 Multivariate Data Analysis Approach for Mass Spectrometry-Based Metabolomics -- 4.1 Introduction -- 4.2 Separation-Based MS Techniques -- 4.2.1 Gas Chromatography-Mass Spectrometry, 4.2.2 Liquid Chromatography-Mass Spectrometry -- 4.2.2.1 Reversed-Phase Liquid Chromatography-Mass Spectrometry -- 4.2.2.2 Hydrophilic Interaction Chromatography-Mass Spectrometry -- 4.2.2.3 Supercritical Fluid Chromatography-Mass Spectrometry -- 4.2.3 Capillary Electrophoresis-Mass Spectrometry -- 4.2.4 Ion Mobility-Mass Spectrometry -- 4.3 Separation-Free MS Techniques -- 4.3.1 Direct Infusion-Mass Spectrometry -- 4.3.2 Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry -- 4.3.3 Mass Spectrometry Imaging -- 4.3.4 Direct Analysis in Real Time-Mass Spectrometry, and 4.4 Tools for MS Result Analysis -- 4.5 Multivariate Statistical Analysis Approach for Data Analysis -- 4.6 Limitations and Challenges -- 4.7 Conclusions and Future Perspectives -- Acknowledgments -- References -- Chapter 5 Mass Spectrometry-Driven Metabolomics for Metabolites and Metabolic Pathway Analysis -- 5.1 Introduction -- 5.2 Mass Spectrometry-Driven Metabolomics for Biomarker Discovery -- 5.3 Data Extraction and Analysis for Metabolites and Metabolic Pathway -- 5.4 Biomarker Identification -- 5.5 Applications -- 5.6 Conclusions -- Acknowledgments -- References

Subject(s)

ISBN

9783527835751 (electronic bk. ; oBook)
352783575X (electronic bk. ; oBook)
9783527835737
3527835733

Note

Chapter 6 Metabolomics as Drivers for Biomarker Discovery and Mechanism Interpretation.

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