Microbiome in neurological disease / volume editor, Tim Sampson
- Published:
- Amsterdam : Academic Press, 2022.
- Physical Description:
- 1 online resource
- Additional Creators:
- Sampson, Tim
Access Online
- Series:
- Contents:
- Intro -- Microbiome in Neurological Disease -- Copyright -- Contents -- Contributors -- Introduction: Unraveling the complex contributions of indigenous microbes to neurological health and disease -- We are not alone -- References -- Chapter One: Intersections of the microbiome and early neurodevelopment -- 1. Microbiota regulation of brain and behavior -- 2. Prenatal and early postnatal microbiota -- 2.1. Maternal intestinal microbiota -- 2.2. The vaginal microbiota -- 3. Impact of microbiota on neurodevelopment: Considerations of the developmental origins of health and disease -- 3.1. Maternal microbiota during pregnancy influences fetal development -- 3.2. Early postnatal microbiota influences fetal development -- 4. Potential mechanisms of microbiota influences on neurodevelopment -- 5. Future directions -- References -- Chapter Two: Microbiome influences on neuro-immune interactions in neurodegenerative disease -- 1. Introduction -- 2. Microbiome influences on microglia -- 3. Microbiome influences on astrocytes -- 4. Microbiome influences on other immune cells -- 5. Gut microbiome studies in human populations -- 6. Gut microbiome studies in model organisms of aging or neurological disease -- 7. Blood brain barrier (BBB) -- 8. Vagus nerve -- 9. Mediators of gut/brain crosstalk -- 9.1. Short chain fatty acids -- 9.2. Aryl hydrocarbon receptor (AHR) and AHR ligands -- 9.3. Lipopolysaccharide -- 9.4. Secondary bile acids -- 9.5. Neurotransmitters -- 10. Therapeutic potential of probiotics and prebiotics to treat neurodegenerative disease -- 11. Future challenges/directions -- Acknowledgments -- Conflict of interests -- References -- Chapter Three: The many genomes of Parkinson´s disease -- 1. Holistic view -- 1.1. Human holobiont -- 1.2. Complexities of PD -- 2. Hologenome -- 2.1. Human genome -- 2.2. Mitochondrial genome -- 2.3. Microbiome., 8.1. Sodium oligomannate -- 8.2. Dietary inulin -- 9. Microbial mediators associated with Alzheimer´s disease -- 9.1. Short-chain fatty acids (SCFAs) -- 9.2. Bile acids -- 9.3. Polysaccharides -- 9.4. Toxins -- 10. Potential use of probiotics for the treatment of AD -- 10.1. Probiotic interventions can improve memory in models of Alzheimer´s disease -- 10.2. Human trials of probiotics for Alzheimer´s disease -- References -- Chapter Six: The microbiota-gut-brain axis in Huntington´s disease -- 1. Microbiota-gut-brain axis -- 1.1. Gut microbiota development -- 1.2. Studying the gut microbiome -- 1.3. Bi-directional communication -- 1.4. Short-chain fatty acids and branched-chain fatty acids -- 2. Gut microbiota disruption -- 2.1. Targeting the gut microbiota -- 3. Huntington´s disease -- 3.1. HD history and prevalence -- 3.2. HD etiology -- 3.3. HD pathology -- 3.4. HD clinical presentation -- 3.5. HD mouse models -- 4. The gut microbiota in HD -- 5. Gut microbiota and HD motor symptoms -- 6. Gut microbiota and HD-induced weight loss -- 7. Gut microbiota and cognition in HD -- 8. Gut microbiota and immune function in HD -- 9. Microbiota-gut-brain axis in HD -- 9.1. Mucosal function -- 9.2. Enteric nervous system and vagal nerve communication -- 9.3. HPA axis -- 10. Gut microbiota and HD sexual dimorphism -- 11. Environment -- 12. Limitations -- 13. Conclusion -- References -- Chapter Seven: Role of the gut microbiome in multiple sclerosis: From etiology to therapeutics -- 1. Microbiome associations studies in MS -- 2. Mechanisms of gut dysbiosis -- 2.1. Leaky gut and systemic inflammation -- 2.2. Modulation of the immune response by the gut microbiota -- 2.2.1. Suppression of the immunoregulatory response -- 2.2.2. Induction of a pro-inflammatory Th1/Th17 response by gut bacteria -- 3. Influence of diet on the pathobiology of MS., and 4. Targeting gut bacteria to treat multiple sclerosis -- 4.1. Probiotic-based therapy to treat autoimmune diseases -- 4.2. Bacteria as drugs (BRUGS) -- 4.3. Prebiotics/diet-based therapy -- 5. Conclusions -- Acknowledgments -- Conflict of interest statement -- References -- Chapter Eight: Interactions between the gut microbiome and ketogenic diet in refractory epilepsy -- 1. Introduction to epilepsy -- 2. Increasing interest in the microbiome and epilepsy -- 3. Ketogenic diet and epilepsy -- 4. Ketogenic diet impact on epilepsy via gut microbiome -- 4.1. Ketogenic diet on the composition of the gut microbiota in epilepsy -- 4.2. Ketogenic diet on the function of the gut microbiome in epilepsy -- 4.3. Ketogenic diet on the gut microbiome in other diseases -- 5. Potential mechanisms for microbial interactions with the ketogenic diet -- 5.1. Microbial effects on host lipid biology -- 5.2. Microbiome responses to variations in dietary fat content and type -- 6. Conclusion -- References -- Chapter Nine: Traumatic spinal cord injury and the contributions of the post-injury microbiome -- 1. Introduction -- 2. Remodeling of the gut microbiome after SCI -- 3. Interactions between the gut microbiome and SCI-induced neurogenic bowel -- 4. SCI-triggered local and systemic immune responses -- 5. Contributions of the microbiome to SCI-associated inflammation in humans -- 6. Microbiome contributions to SCI-associated inflammation in experimental models -- 7. SCI microbiome association with gut permeability after injury -- 8. Microbiome manipulations with therapeutic potential for SCI recovery -- 8.1. Fecal microbiome transplants -- 8.2. Probiotic therapeutics -- 8.3. Selective antibiotic treatment -- 8.4. Beneficial microbiome-related metabolites -- 9. Looking broadly into the future at microbiome effects on SCI -- Acknowledgments -- References.
- Subject(s):
- ISBN:
- 9780323991759 (ePub ebook)
0323991750
9780323991766 (hbk.) - Note:
- Preface: Unraveling the complex contributions of the microbiome to neurological diseases
Timothy Sampson
1. Intersections of the microbiome and early neurodevelopment
Helen Vuong
2. Microbiome influences on neuro-immune interactions
Malu G. Tansey and Brittney Otero
3. The genomes of Parkinson's disease
Haydeh Payami
4. Experimental contributions of the microbiome to Parkinson's disease
Ali Keshavarzian, Christopher Goetz, Deborah Ann Hall, Richard A. Manfready, Robin Voigt and Christopher Forsyth
5. The foundations of microbiome contributions to Alzheimer's disease
Sam Sisodia and Hemraj Dodiya
6. Immunologic pathways by which the gut microbiota influences Alzheimer's disease
Laurie Cox and Carolin Wasen
7. Role of the gut microbiome in Huntington's Disease
Anthony Hannan
8. The microbiome in multiple sclerosis, from etiology to therapeutics
Ashutosh K. Mangalam
9. The microbiome and epilepsy
Elaine Hsiao
10. Influence of the microbiome in recovery of traumatic nervous system injury
Timothy Sampson and Adam Hamilton
11. Role of the microbiome in chronic and visceral pain
Michael Burton
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