Actions for THE EFFECT OF NEUTRONS AND OTHER RADIATIONS ON OCULAR LENS. Progress Report for contract period January 1961-December 1961

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THE EFFECT OF NEUTRONS AND OTHER RADIATIONS ON OCULAR LENS. Progress Report for contract period January 1961-December 1961

Author
Kinsey, V. E.
Published
United States : [publisher not identified], 1961.
[Oak Ridge, Tennessee] : [U.S. Atomic Energy Commission], 1961.
Physical Description
microopaque : positive ; 8 x 13 cm

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Summary
The transport of amino acids across the blood aqueous barriers, the capsule and epithelium of the lens, and some factors which affect the processes involved were studied. Investigations were also made of the retative concentration of free amino acids in the aqueous and vitreous humors, lens, and plasma of normal animals, and some experiments were performed in which the transport of potassium into the lens was determined. Carbon labeled alpha-amino isobutyric acid and other carbon-11 labeled compounds show that aspartic acid reduces the transport of flutamic acid, but not the basic amino acids. Three different mechanisms are involved in transportrng amino acids into the lens. Elevated concentrations of glucose inhibit amino acid transport, and other sugars have similar effects. Evidence that naturally occurring amino acids are actively transported across the ciliary epithelial cells is shown. An incubation medium was developed which allows a lens dispersion to consume glucose and produce lactate at rates which are accepted as normal for intact lenses incubated in Tyrode's solut~on. The use of this medium in the study of fructose production in the lens culminated in a report showing the source of fructose in the lens, the mechanism by which it is formed, and speculation as to the ffunction of this mechanism. The relative concentration of free amino acids in aqueous tumor in the posterior and anterior chambers, vitreous humor, and plasma of rabbits was determined by ion exchange chromatography. (P.C.H.)
Report Numbers
TID-13867
Other Subject(s)
Collection
U.S. Atomic Energy Commission depository collection.
Note
DOE contract number: AT(11-1)-152
NSA number: NSA-15-030456
OSTI Identifier 4834613
Research organization: Kresge Eye Inst., Detroit.
View MARC record | catkey: 42249469