Actions for FURTHER INVESTIGATIONS CONCERNING THE EFFECTS OF COSMIC RAY HEAVY NUCLEI AND OF MICROBEAMS ON MAMMALIAN SKIN. Progress Report for January 1, 1962-December 31, 1962

Email RIS file
Bookmark
Report an Issue

FURTHER INVESTIGATIONS CONCERNING THE EFFECTS OF COSMIC RAY HEAVY NUCLEI AND OF MICROBEAMS ON MAMMALIAN SKIN. Progress Report for January 1, 1962-December 31, 1962

Author
Chase, H. B.
Published
United States : [publisher not identified], 1962.
[Oak Ridge, Tennessee] : [U.S. Atomic Energy Commission], 1962.
Physical Description
microopaque : positive ; 8 x 13 cm

Availability

I Want It
I Want It

Finding items...

Summary
Histological examination of growing hair follicles from 1 to 96 hr after exposure to doses of x radiation between 200 and 2000 rads showed that a dose of 200 rads is subthreshold for subsequert greying and for temporary epilation. Nevertheless, at 20 to 24 hr damage to the hair bulb is pronounced and appears essentially equivalent to that following a dose of 2000 rads. At 38 hr there is recovery from the 200 rad dose and cortinued disorganization from the 2000 rad dose. It was concluded that 200 rads x radiation is a subthreshold dose only in terms of gross appearance of hair or in terms of histological appearance of the skin several days after exposure. A dose of 200 rads produces extensive tissue disorganization of the bulb and disorientation of melanocytes, but does not prevent rapid tissue recovery and subsequert normal differentiation of the hair and inner sheath. Rather than reflecting thresholds of damage, the data indicate that there are thresholds beyond which full recovery of tissue does not occur. Results of studies of the effects on skin of stripped carbon nuclei of 10-Mev/ nucleon energy indicated a threshold for greying at 50 rads. Studies using a collimated electron beam with exposures to the skin through slits 200 microns wide gave additional evidence that the orientation of the slit relative to the slope of the hair follicle makes a difference in effect. Results are included from a study on the response of the melanoblast and melanocyte cells in the eyes of neonatal mice to 1000 r x radiation. By irradiating the eyes at different times following birth it was shown that the reduction in eye pigmentation is an extension of the radiosensitivity of the developing retina and is only an indirect effect on the associated epithelial melanocytes. The sequence of events in the hair growth cycle was investigated as part of a study on radioinduced epilation. (C.H.)
Report Numbers
TID-17676
Other Subject(s)
Collection
U.S. Atomic Energy Commission depository collection.
Note
DOE contract number: AT(30-1)-2018
NSA number: NSA-17-010363
OSTI Identifier 4713468
Research organization: Brown Univ., Providence.
View MARC record | catkey: 42250837