Actions for AN INVESTIGATION INTO THE PHARMACOLOGICAL PROPERTIES OF ANTI-IRRADIATION DRUGS. Progress Report. REDUCTION OF DIMETHYLSULFOXIDE TO DIMETHYLSULFIDE IN THE CAT
AN INVESTIGATION INTO THE PHARMACOLOGICAL PROPERTIES OF ANTI-IRRADIATION DRUGS. Progress Report. REDUCTION OF DIMETHYLSULFOXIDE TO DIMETHYLSULFIDE IN THE CAT
Progress is reported in studies on the pharmacological properties of aminoethylisothiaronium bromide hydrobromide (AET) and dimethyl sulfoxide (DMSO) in mice and cats. The mechanisms of action of these radioprotective compounds were studied in an attempt to reduce their toxic effects when given to higher animals. Data are presented on the effects of AET on the central nervous system and the effects of DMSO on blood pressure, heart, respiration, gut mobility, and nervous system in the test animals. (C.H.)