Actions for Mechanism of post-replication repair in mammalian cells. [DNA strand breaks].

Email RIS file
Bookmark
Report an Issue

Mechanism of post-replication repair in mammalian cells. [DNA strand breaks].

Author
Doniger, J.
Published
United States : [publisher not identified], 1978.
[Oak Ridge, Tennessee] : [U.S. Atomic Energy Commission], 1978.
Physical Description
microfiche : negative ; 11 x 15 cm

Availability

I Want It
I Want It

Finding items...

Summary
Two mechanisms proposed to explain post-replication repair of DNA strand breaks in mammalian cells are discussed. The gapped synthesis model predicts that daughter strands replicated on damaged templates will contain discontinuities. The size of the nascent strands should be equal to the distance between the damages. Moreover, the rate of fork movement should be independent of the rate of discontinuity repair. The replicative bypass model predicts that there will be no discontinuities in the daughter strands. Blocking repair would prevent fork movement. The experiments reported using cultured Chinese hamster cells were performed in order to distinguish between these two mechanisms.
Report Numbers
BNL-24326; CONF-780226-10
Other Subject(s)
Collection
U.S. Atomic Energy Commission depository collection.
Note
DOE contract number: EY-76-C-02-0016
OSTI Identifier 6850510
Research organization: Brookhaven National Lab., Upton, N.Y. (USA).
Research organization: National Cancer Inst., Bethesda, Md. (USA).
View MARC record | catkey: 42515385