Effects of intracavitary irradiation by californium-252

Author: Sullivan, M. F.
Published: United States : [publisher not identified], 1972.
[Oak Ridge, Tennessee] : [U.S. Atomic Energy Commission], 1972.
Physical Description: microfiche : negative ; 11 x 15 cm
Additional Creators: Beamer, J. L. and Mahony, T. D.

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Summary

From effects of neutron irradiation upon cell function conference; Munich, F. R. Germany (22 Oct 1973). Improvements in neutron dosimetry and additional information about the effects of neutrons caused renewed interest in fast neutrons for cancer therapy. The availability of encapsulated /sup 252/Cf has introduced the need for data on the response of normal tissues that are at risk during an intracavitary exposure to a /sup 252/Cf implant. The anatomical characteristics of the Hanford Miniature Swine make them useful for studies to determine the short- and long-term effects of intracervically implanted /sup 226/ Ra or /sup 252/Cf. Capsules containing 50 mg Ra or 50 mu g Cf were inserted in the cervix with a tandem applicator by an after-loading technique. Therrmoluminescent dosimeters were attached to organs adjacent to the sources during laparotomy in some animals. The Ra pigs received a fractionated dose calculated as 7,000 to 14,000 rad at a point 2 cm lateral to the source. The Cf swine received between 2,000 and 6,000 rad. Pigs were either killed weekly to determine the early changes or brought to autopsy later because of delayed effects. Others are being killed from 1 to 3 yr after treatment for studies of long-terna effects. Acute damage iwo weeks after 10,500 rad from /sup 226/Ra was similar to that caused by 2,800 rad from /sup 252/Cf. Damage consisted of a well defined ulcer on the anterior wall of the rectum adjacent to the source location. The ulcer did not heal and persisted irto the late period as a chronic radiation ulcer. The urinary bladder, except at the high doses, did not show gross ulceration, but a diffuse erythema occurred in the trigonal or supratrigonal region of the bladder with varying degrees of petechial hemorrhage. These changes provide an acute RBE of greater than six for both the rectum and urinary tract and indications are that the RBE for long-term effects will be larger than for acute radiation injury. (auth)

Report Numbers

BNWL-SA-4679; CONF-731038-1; SM-179-29

Other Subject(s)

Collection

U.S. Atomic Energy Commission depository collection.

Note

DOE contract number: AT(45-1)-1830
NSA number: NSA-29-018619
OSTI Identifier 4345029
Research organization: Battelle Pacific Northwest Labs., Richland, Wash. (USA).

Funding Information

Sponsored by US Atomic Energy Commission (AEC).

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