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New Insights into Systemic Sclerosis

Published
IntechOpen 2019
Physical Description
1 online resource (160 p.)
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Language Note
English
Restrictions on Access
Open Access Unrestricted online access
Summary
Systemic sclerosis (scleroderma) is an incurable connective tissue disease of unknown etiology. Three key processes play a pivotal role in the pathogenesis: immune dysregulation and inflammation, endothelial injury and vasculopathy, and fibrosis. Tissue fibrosis is the dominant and characteristic feature that affects the skin and visceral organs. Life expectancy of scleroderma patients has improved over recent years, mainly because of better treatment of organ involvement and complications; however, no curative disease-modifying therapies exist to date. This book aims to provide students, trainees, rheumatologists, and other specialists interested in this disease with a comprehensive overview of novel pathogenetic mechanisms, management approaches, and therapeutic targets of several major vascular and fibrotic manifestations, and is useful insight into a number of usually neglected aspects of scleroderma.
Subject(s)
Other Subject(s)
ISBN
9781839622045
9781839622052
9781839622069
intechopen.78254
Collection
DOAB Library.
Terms of Use and Reproduction
Creative Commons https://creativecommons.org/licenses/by/3.0/
View MARC record | catkey: 43685718