Actions for Design, construction, and application of XRF systems for analysis of trace elements in clinical, biological, and environmental samples. Progress report, August 1, 1975--June 30, 1976

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Design, construction, and application of XRF systems for analysis of trace elements in clinical, biological, and environmental samples. Progress report, August 1, 1975--June 30, 1976

Author
Laurer, G. R.
Published
United States : [publisher not identified], 1976.
[Oak Ridge, Tennessee] : [U.S. Atomic Energy Commission], 1976.
Physical Description
microfiche : negative ; 11 x 15 cm
Additional Creators
Kneip, T. J.

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Summary
A separation technique has been developed allowing preparation of fixed volumes of rbc's and plasma. Replicate sampling shows rbc and plasma specimen weights of 43 +- 1.4 mg and 36 +- 1.9 mg, eliminating large background variation due to weight differences of whole blood specimens. An improved specimen geometry has significantly increased the signal to background ratio for low Z elements and with the separation technique, allows quantitative determination with good precision, of changes in the levels of Cl, K, Ca, Fe, Cu, Zn and Br, and in the intra/extra cellular ratios of these elements. Pb is detectable at ''normal'' levels (20 ..mu..g percent), depending on hematocrit with a one-minute count using 3 sigma confidence. Measurements of primate blood indicate a possible rise in bromine level with pregnancy in baboons. In preparation for use in proton-accelerator room, a wheel-based, rack-mount has been constructed which allows transportation of the XRF system for on-site and off-site analyses. (auth)
Report Numbers
COO-3040-5
Other Subject(s)
Collection
U.S. Atomic Energy Commission depository collection.
Note
DOE contract number: E(11-1)-3040
OSTI Identifier 7141847
Research organization: New York Univ., N.Y. (USA). Medical Center.
Funding Information
Sponsored by US Energy Research and Development Administration (ERDA).
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