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Comparison of normal and asthmatic subjects' responses to sulfate pollutant aerosols

Author
Utell, M. J.
Published
United States : [publisher not identified], 1980.
Springfield, Va. : National Technical Information Service, [approximately 1980]
Physical Description
microfiche : negative ; 11 x 15 cm
Additional Creators
Hyde, R. W. and Morrow, P. E.

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Summary
Epidemiological studies support an association between elevated levels of sulfates and acute respiratory disease. To determine if these pollutants produce airway hyperreactivity, 16 normal and 17 asthmatic subjects inhaled a control NaCl aerosol and the following sulfates: ammonium sulfate, sodium bisulfate, ammonium bisulfate, and sulfuric acid. A Lovelace generator produced particles with an average MMAD of approx. 1.0 ..mu..m (sigma/sub g/ approx. = 2.0) and concentrations of 0.1 and 1.0 mg/m/sup 3/. By double-blind randomization, all subjects breathed these aerosols for a 16-minute period. To determine if sulfate inhalation caused increased reactivity to a known bronchoconstrictor, all subjects inhaled carbachol following each 16-minute exposure. Before, during, and after exposure, pulmonary function studies were performed. When compared to NaCl, sulfate (1 mg/m/sup 3/) produced significant reductions in airway conductance and flow rates in asthmatics. The two most sensitive asthmatics demonstrated changes even at 0.1 mg/m/sup 3/ sulfate. To a far more significant degree, the bronchoconstrictor action of carbachol was potentiated by sulfates more or less in relation to their acidity in normals and asthmatics.
Report Numbers
UR-3490-1886; CONF-8009111-1
Other Subject(s)
Collection
NTIS collection.
Note
DOE contract number: AC02-76EV03490
OSTI Identifier 7096979
Research organization: Rochester Univ., NY (USA). Dept. of Radiation Biology and Biophysics.
View MARC record | catkey: 45336915