Atropisomerism in asymmetric organic synthesis : challenges and applications / edited by Shinobu Takizawa and Mohamed S. H. Salem
- Published
- Weinheim, Germany : Wiley-VCH, [2025]
- Physical Description
- 1 online resource (355 pages)
- Additional Creators
- Takizawa, Shinobu and Salem, Mohamed S. H.
Access Online
- Contents
- Cover -- Title Page -- Copyright -- Contents -- Preface -- About the Editors -- Part I Atroposelective Synthesis -- Chapter 1 Introduction -- 1.1 Molecular Chirality and Atropisomerism -- 1.1.1 Molecular Chirality -- 1.1.2 Axial Chirality and Atropisomerism -- 1.2 Atropisomerism in Asymmetric Organic Synthesis -- 1.3 Atropisomerism: Challenges and Applications -- 1.3.1 Axially Chiral Ligands and Organocatalysts -- 1.3.2 Natural Product Synthesis -- 1.3.3 Atropisomerism in Drug Discovery and Development -- References, Chapter 2 Iron- and Ruthenium-Catalyzed Atroposelective Synthesis of Axially Chiral Compounds -- 2.1 Introduction -- 2.2 Oxidative Homo-coupling of 2-Naphthols to BINOL and Its Derivatives -- 2.3 Oxidative Cross-coupling of 2-Naphthols to Asymmetric BINOLs -- 2.4 Oxidative Spirocyclization of 2-Naphthols -- 2.5 Conclusion -- References -- Chapter 3 Vanadium-Catalyzed Atroposelective Coupling of Arenols and Application in the Synthesis of Polycyclic Heteroaromatics (PHAs) -- 3.1 Introduction -- 3.2 Chiral Vanadium Catalysis in Homo-Coupling of Hydroxycarbazoles, 3.3 Chiral Vanadium Catalysis in Hetero-Coupling of Hydroxycarbazole with 2-Naphthols -- 3.4 Enantioselective Synthesis of Oxa[9]helicenes via Chiral Vanadium Complex-Catalyzed Homo-Couplings of Polycyclic Phenols -- 3.5 Enantioselective Synthesis of Oxaza[7]dehydrohelicenes via Chiral Vanadium Complex-Catalyzed Hetero-Couplings of 3-Hydroxycarbazoles and 2-Naphthols -- 3.6 Summary and Conclusion -- References -- Chapter 4 Atroposelective Suzuki-Miyaura Coupling Toward Axially Chiral Biaryls: Mechanistic Insight -- 4.1 Introduction, 4.2 Mechanism Insight of SMC Reaction and Enantiodetermining Step -- 4.3 Asymmetric SMC Reaction -- 4.3.1 Examples of Early Studies -- 4.3.2 Consideration of the Asymmetric SMC: Cases Dependent on a Directing Group -- 4.3.3 Consideration of the Asymmetric SMC: Cases Independent of a Directing Group -- 4.4 Conclusion -- References -- Chapter 5 Organocatalytic Enantioselective Formation of Atropisomers -- 5.1 Introduction -- 5.2 Aminocatalysis -- 5.2.1 Atropisomeric Synthesis of C C Biaryls via Aminocatalysis -- 5.2.2 Atropisomeric Synthesis of C C Non-biaryls via Aminocatalysis, and 5.2.3 Atropisomeric Synthesis of C N Scaffolds via Aminocatalysis -- 5.3 Brønsted Base Catalysis -- 5.3.1 Atropisomeric Synthesis of C C Biaryls and Heterobiaryls via Base Catalysis -- 5.3.2 Atropisomeric Synthesis of C C Non-biaryls via Base Catalysis -- 5.3.3 Atropisomeric Synthesis of C N Scaffolds via Base Catalysis -- 5.3.4 Atropisomeric Synthesis of N N Scaffolds via Base Catalysis -- 5.4 Phase Transfer Catalysis -- 5.4.1 Atropisomeric Synthesis of C C Biaryls, Heterobiaryls, and Non-biaryls via PTC -- 5.4.2 Atropisomeric Synthesis of C N Scaffolds via PTC
- Subject(s)
- ISBN
- 9783527844258 electronic book
3527844252 electronic book
9783527844234 electronic book
3527844236 electronic book
9783527352838 hardcover
352735283X hardcover - Note
- Description based upon print version of record.
5.4.3 Atropisomeric Synthesis of C O Scaffolds via PTC
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