Tumor production in Syrian hamsters following inhalation of PuO2--ZrO2 aerosol

Author: Thomas, R. G.
Published: United States : [publisher not identified], 1978.
[Oak Ridge, Tennessee] : [U.S. Atomic Energy Commission], 1978.
Physical Description: microfiche : negative ; 11 x 15 cm
Additional Creators: Smith, D. M., 1938-

Availability

Finding items...

Summary

Syrian golden hamsters of both sexes were exposed to aerosols of ZrO/sub 2/ containing PuO/sub 2/. The starting material in the aerosol generator also had a small amount of /sup 57/Co added as a tracer. The mixture of all three constituents was nebulized and the droplets passed through a heating column at 1000/sup 0/C. Aerosol sampling was accomplished with a cascade impactor and electrostatic precipitator. The median aerodynamic diameters in all inhalation runs were approximately 2 ..mu..m with a geometric standard deviation of 2. One exposed group of 60 hamsters had 6-day lung burdens averaging 100 nCi. This group had a lung tumor incidence of 44% with an even distribution of adenomas and carcinomas. Two other groups had average 6-day lung burdens of 80 to 90 nCi plus 55 nCi of intravenously injected spheres localized in the lung. These animals had tumor incidences of approximately 30%.

Report Numbers

LA-UR-78-644; CONF-771109-98

Other Subject(s)

Collection

U.S. Atomic Energy Commission depository collection.

Note

DOE contract number: W-7405-ENG-36
OSTI Identifier 5111203
Research organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States).

View MARC record | catkey: 47044350