Actions for Altered growth and RNA metabolism in cultured Chinese hamster ovary cells exposed to low levels of cadmium. Progress report, July 1, 1976--June 30, 1977
Altered growth and RNA metabolism in cultured Chinese hamster ovary cells exposed to low levels of cadmium. Progress report, July 1, 1976--June 30, 1977
This report summarizes measurements of the uptake and intracellular distribution of cadmium in cultured Chinese hamster cells exposed to CdCl/sub 2/ at growth medium concentrations ranging from 2 x 10/sup -7/ M Cd/sup + +/, which shows no effect on cell proliferation, to 3 x 10/sup -6/ M Cd/sup + +/, which stops cell division within 24 h after beginning exposure. These studies demonstrate a rapid accumulation of intracellular cadmium during the first 24 h of growth in Cd/sup + +/-containing medium.