Actions for Non-regulatory and cost-effectiveness control of carcinogenic hazard. The beginnings : a methodology for using animal data to decrease uncertainty in human risk of carcinogens released by energy technologies

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Non-regulatory and cost-effectiveness control of carcinogenic hazard. The beginnings : a methodology for using animal data to decrease uncertainty in human risk of carcinogens released by energy technologies

Author
Crouch, E. A. C.
Published
United States : [publisher not identified], 1982
Springfield, Va.: National Technical Information Service, [approximately 1982]
Physical Description
microfiche : negative ; 11 x 15 cm
Additional Creators
Feller, J., Fiering, M. B., Hakanoglu, E., Wilson, R., and Zeise, L.

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Summary
A logical cost effective procedure for assessing carcinogenic risk associated with emerging energy technologies is outlined. All chemicals are assumed to be carcinogenic with a potency that has to be measured. In this scheme a non-carcinogen is a chemical with zero potency. If the carcinogenic potency in animals has not been measured, it may be assumed from an a priori measure. Using estimates of potency, exposure, and an interspecies factor (which also accounts for uncertainties in extrapolating the animal data to man), an estimate of risk and the uncertainty associated with that estimate is made, together with upper bounds on the risk. If the upper bound is small the risk is negligible and can be ignored. If it is large, the exposure at the level proposed should not be permitted. However further information may be obtained which changes the risk estimate or lowers the uncertainty so that the upper bound on the risk is reduced. Notice that estimation of the uncertainty is as important as estimation of a best value of risk.
Report Numbers
DE83009531; DOE/EV/10598-1
Other Subject(s)
Collection
NTIS collection.
Note
DOE contract number: AC02-81EV10598
OSTI Identifier 6369004
Research organization: Harvard Univ., Cambridge, MA (USA). Energy and Environmental Policy Center.
View MARC record | catkey: 47329477