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Review of the literature on enzymatic reduction of nitrocompounds

Author
Hadley, W. M.
Published
United States : [publisher not identified], 1983
Springfield, Va.: National Technical Information Service, [approximately 1983]
Physical Description
microfiche : negative ; 11 x 15 cm

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Summary
If more accurate assessment of the risk associated with human exposure to nitrocompounds (NCs) in combustion products, drugs, industrial chemicals and agricultural chemicals are to be made. An understanding of the enzymatic reduction of NCs must be acquired. This review covers the literature through November 1982 on reduction by enzymes of nitro groups attached to organic compounds. Much of the nitroreduction literature has focused on the metabolism of p-nitrobenzoic acid, 4-nitroquinoline 1-oxide, the nitrofurans, and the nitroimidazoles. A few papers report the reduction of other NCs such as the nitrophenols, nitrotoluenes and nitrobenzenes. Only very limited information is available on the reductive metabolism of multi-ring NCs.
Report Numbers
DE84012995; LMF-104
Other Subject(s)
Collection
NTIS collection.
Note
DOE contract number: AC04-76EV01013
OSTI Identifier 7192526
Research organization: Inhalation Toxicology Research Inst., Albuquerque, NM (USA).
View MARC record | catkey: 47342610