This study was initiated to determine the extent of predation by resident populations of native and introduced fish on juvenile salmonids in main stem Columbia River Reservoirs. The John Day Reservoir and tailrace was selected as the study area. First year objectives were: (1) determine whether native and introduced predators preyed on juvenile salmonids; (2) determine which species were major predators; and (3) locate areas where predation was most intense. Results indicated that juvenile salmonids were consumed by all four predatory fish species studied: northern squawfish (Ptychocheilus oregonensis), walleye (Stizostedion vitreum vitreum), smallmouth bass (Micropterus dolomieu), and channel catfish (Ictalurus punctatus). However, degree of predation varied among predators as a function of spatial distribution, apparent abundance, size, and temporal feeding behavior. 15 figs., 16 tabs.