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Distribution of sulfhydryl boranes in mice and rats

Author
Slatkin, D. N.
Published
United States : [publisher not identified], 1986
Springfield, Va.: National Technical Information Service, [approximately 1986]
Physical Description
microfiche : negative ; 11 x 15 cm
Additional Creators
Fairchild, R. G., Laster, B. H., and Micca, P. L.

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Summary
The distribution of boron in mice bearing transplanted Harding-Passey melanomas after rapid and slow administration of monomer were studied. Thin layer chromatographic analysis of the corresponding infusion solution revealed a slow-moving principal band that was later shown to correspond to Na4B/sub 24/H/sub 22/S2, the dimer of Na2B/sub 12/H/sub 11/SH. It was found that while monomer and chemically synthesized dimer yielded similar boron concentrations when they were given rapidly intraperitoneally to mice, the dimer yielded higher boron concentrations in mouse melanoma and higher melanoma-blood boron concentration when each was infused slowly intraperitoneally for 8 to 9 days. Studies have been started on the uptake of dimer into an intracerebrally implanted rat glioma. Boron levels in the rat glioma and in the mouse melanoma from slow intraperitoneal infusion of proportionately comparable amounts of dimer, are similar. However, after these slow infusions boron levels in rat blood are about as high as boron levels in rat brain tumor. 6 refs., 1 fig., 4 tabs.
Report Numbers
DE86009939; BNL-37836; CONF-860155-2
Other Subject(s)
Collection
NTIS collection.
Note
DOE contract number: AC02-76CH00016
OSTI Identifier 5806115
Research organization: Brookhaven National Lab., Upton, NY (USA).
View MARC record | catkey: 47363985