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Molecularly targeted therapy for childhood cancer [electronic resource] / Peter J. Houghton, Robert J. Arceci, editors

Published:
New York : Springer, [2010]
Copyright Date:
©2010
Physical Description:
1 online resource (xviii, 536 pages) : illustrations (some color)
Additional Creators:
Houghton, Peter J. and Arceci, Robert
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Contents:
The Emerging Era of Targeted Therapy in Childhood Acute Lymphoblastic Leukemia; Molecular Targeted Therapies in T-CellAcute Lymphoblastic Leukemia; Molecularly Targeted Therapy for Infant ALL; Targeted Therapeutic Approaches for AML; Acute Promyelocytic Leukaemia; Down Syndrome and Acute Myeloid Leukemia: An Unique Genetic Sensitivity to Chemotherapy; Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia (JMML); Chronic Myeloid Leukemia: Pathophysiology and Therapeutics; Molecularly Targeted Therapies in Pediatric Myelodysplastic Syndromes.
Summary:
Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular 'drivers' can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.
Subject(s):
ISBN:
9780387690629
038769062X
Note:
AVAILABLE ONLINE TO AUTHORIZED PSU USERS.
Bibliography Note:
Includes bibliographical references and index.
View MARC record | catkey: 6762962