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Phosphoinositide 3-kinase in health and disease. Volume 2 [electronic resource] / Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt, editors

Published
Berlin ; Heidelberg : Springer, [2011]
Copyright Date
©2011
Physical Description
1 online resource (x, 304 pages) : illustrations
Additional Creators
Rommel, Christian, Vanhaesebroeck, Bart, and Vogt, P. K. (Peter K.), 1932-
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Series
Contents
Phosphoinositide 3-kinase in Health and Disease; Volume 2; Contents; Contributors; PI3K: From the Bench to the Clinic and Back; Oncogenic Mutations of PIK3CA in Human Cancers; Structural Effects of Oncogenic PI3Ka Mutations; Comparing the Roles of the p110a and p110beta Isoforms of PI3K in Signaling and Cancer; Phosphatidylinositol 3-Kinase: The Oncoprotein; AKT Signaling in Physiology and Disease; Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse; PI3K as a Target for Therapy in Haematological Malignancies; Clinical Development of Phosphatidylinositol-3 Kinase Pathway Inhibitors.
Summary
PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target.
Subject(s)
ISBN
9783642148163 (electronic bk.)
3642148166 (electronic bk.)
Note
AVAILABLE ONLINE TO AUTHORIZED PSU USERS.
Bibliography Note
Includes bibliographical references and index.
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