Nuclear receptors in drug metabolism [electronic resource] / edited by Wen Xie
- Drug metabolism : significance and challenges -- Establishing orphan nuclear receptors PXR and CAR as xenobiotic receptors -- Nuclear receptor-mediated regulation of phase II conjugating enzymes -- Nuclear receptor-mediated regulation of drug transporters -- Structure and function of PXR and CAR -- Xenobiotic receptor cofactors and coregulators -- Animal models of xenobiotic nuclear receptors and their utility in drug development -- Nuclear receptors and drug-drug interactions of prescription drugs and herbal medicines -- Genetic variants of xenobiotic receptors and their implications in drug metabolism and pharmacogenetics -- Beyond PXR and CAR, regulation of xenobiotic metabolism by other nuclear receptors -- Emerging role of retinoid-related orphan receptor (ROR) and its cross talk with LXR (liver X receptor) in the regulation of drug-metabolizing enzymes.
- AVAILABLE ONLINE TO AUTHORIZED PSU USERS.
- Bibliography Note:
- Includes bibliographical references and index.
- Reproduction Note:
- Electronic reproduction. Hoboken, N.J. : Wiley InterScience, 2009. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on Jan. 19, 2009). Access may be restricted to users at subscribing institutions.
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